Latest Preprint Reviews

Microbiota-induced plastic T cells enhance immune control of antigen-sharing tumors

Najar et al. (BioRxiv) DOI:10.1101/2024.08.12.607605

Monocyte-derived cells but not Microglia cause Oxidative Tissue Damage in Neuroinflammation

Villar-Vesga et al. (BioRxiv) DOI: 10.1101/2024.09.18.612891

PD-1 controls differentiation, survival, and TCR affinity evolution of stem-like CD8+ T cells

Hor et al. (BioRxiv) DOI: 10.1101/2024.08.02.606241

Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells

Capera et al. (BioRxiv) DOI: 10.1101/2024.08.13.607831

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

Chowdhury et al. (BioRxiv) DOI: 10.1101/2023.02.10.527741

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypo proliferation

Feng X et al. (BioRxiv) DOI:10.1101/2024.03.04.583299

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

Stevens et al. (BioRxiv) DOI:10.1101/2024.04.09.588427

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or resiratory viral infections

Ngo C. et al. (BioRxiv) DOI:10.1101/2024.05.20.594961

B cell-mediated antigen presentation promotes adverse cardiac remodeling in chronic heart failure

Lovell et al. (BioRxiv) DOI:10.1101/2024.05.08.593153

Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans

Asiimwe et al. (BioRxiv) DOI: 10.1101/2024.03.07.583906

Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells

Alma-Martina Cepika, et al. (BioRxiv) DOI: 10.1101/2024.03.07.582969

Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells.

Kaltenbach et al. (BioRxiv) DOI:10.1101/2024.02.23.581763

Low Avidity T cells drive endogenous tumor immunity in mice and humans

Singhaviranon et al. (Research Square) DOI: 10.21203/rs.3.rs-3903457/v1

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

Ben-Chetrit et al. (BioRxiv) DOI:10.1101/2023.10.24.563749

CD4+ TRM sustain the chronic phase of auto-immune neuroinflammatory disease

Pignata et al. (BioRxiv) DOI:10.1101/2024.03.26.586880

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

Bin Sun, et.al. (BioRxiv) DOI: 10.1101/2024.03.18.585442

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

Yi et al. (BioRxiv) DOI:10.1101/2024.02.26.582108

Interleukin-1 receptor antagonist is a conserved driver of tuberculosis

Kotov. et al. (BioRxiv) DOI: 10.1101/2023.10.27.564420

Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers

Schiepers A. et al. (BioRxiv) DOI: 10.1101/2023.12.15.571936

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells

Isaacs, JF et al. (BioRxiv) DOI: 10.1101/2024.03.15.585252v1

Microbiota encoded fatty-acid metabolism expands tuft cells to protect tissues homeostasis during Clostridioides difficile infection in the large intestine

Kellogg et al. (BioRxiv) DOI: 10.1101/2024.01.29.574039

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

Di Gioia et al. (BioRxiv) DOI: 10.1101/2023.11.21.568047

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

Enrique Gabamdé-Rodrigez, Gonzalo Soto-Heredero, et al. (BioRxiv) DOI: 10.1101/2024.01.26.577360

IQGAP2 regulates blood-brain barrier immune dynamics

Katdare KA et al. (BioRxiv) DOI: 10.1101/2023.02.07.527394

Tuft cell derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen.

Ndjim M. et al. (BioRxiv) DOI: 10.1101/2023.12.08.570757

Cancer immunotherapy responses persist after lymph node resection

Zhou H et al. (BioRxiv) DOI: 10.1101/2023.09.19.558262

Lymphatic vessel transit seeds precursors to cytotoxic resident memory T cells in skin draining lymph nodes

Heim, et al. (BioRxiv) DOI: 10.1101/2023.08.29.555369

Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity

Appios A, Daview J, Sirvent S, et al. (BioRxiv) DOI: 10.1101/2023.11.13.566862

Interpretable inflammation landscape of circulating immune cells

Jimenez-Gracia et al. (BioRxiv) DOI: 10.1101/2023.11.28.568839

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

Kim et al. (BioRxiv) DOI:10.1101/2023.11.16.567402

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s Disease

Li et al. (BioRxiv) DOI: 10.1101/2023.09.30.560293

Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation

Iamsawat et al. (BioRxiv) DOI: 10.1101/2023.09.23.559152

CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β

Prise I.E. et al. (BioRxiv) DOI: 10.1101/2023.08.21.553672

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

Kwok D.W. et al. (BioRxiv) DOI: 10.1101/2023.10.19.563178

An “alert state” ribosome population acts as a master regulator of cytokine-mediated processes

Dopler et al. (BioRxiv) DOI: 10.1101/2023.10.17.562425

Iron is critical for mucosal-associated invariant T cell metabolism and effector functions.

Eimear R. et al. (Research Square) DOI: 10.21203/rs.3.rs-3358434/v1

A spatial human thymus cell atlas mapped to a continuous tissue axis

Yayon*, Kedlian*, Boehme* et al. (BioRxiv) DOI: 10.1101/2023.10.25.562925

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

Shu D.H. et al. (BioRxiv) DOI: 10.1101/2023.10.16.562104

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

Horn V. et al. (BioRxiv) DOI: 10.1101/2023.10.01.560386

Maternal IL-10 restricts fetal emergency myelopoiesis

Collins A. et al. (BioRxiv) DOI: 10.1101/2023.09.13.557548

Murine classical monocyte subsets display distinct functions and fates

Trzebanski et al. (BioRxiv) DOI: 10.1101/2023.07.29.551083

Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation

Dhariwala M.O. et al. (BioRxiv) DOI:10.1101/2023.09.29.560039

Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases

Faust H. et al. (bioRxiv) DOI: 10.1101/2023.05.16.540975

TAPIR: a T-cell receptor language model for predicting rare and novel targets.

Fast et al. (BioRxiv) DOI: 10.1101/2023.09.12.557285

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production

Bao, B. et al. (BioRxiv) DOI: 10.1101/2023.09.05.555400

HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells

Wu et al. (BioRxiv) DOI: 10.1101/2023.08.31.555662

Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS

Mosegaard S. et al. (BioRxiv) DOI: 10.1101/2023.08.30.555512

Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge

Coates M.L. et al. (BioRxiv) DOI: 10.1101/2023.09.15.558006

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

Burton O*, Bricard O* et al. (BioRxiv) DOI: 10.1101/2023.08.14.553196

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets.

Ramanan D. et al. (BioRxiv) DOI: 10.1101/2023.05.17.541199

Memory Th1 cells modulate heterologous diseases through innate function.

Rakebrandt*, Yassini* et al. (BioRxiv) DOI: 10.1101/2023.03.22.533799

T:B cell communication in ectopic lymphoid follicles in CNS autoimmunity

Kolz A. et al. (bioRxiv) DOI:10.1101/2023.06.01.543004

Pannexin-1 channels promote CD8+ T cell effector and memory responses through distinct intracellular pathways

Trupti Vardam-Kaur et al. (BioRxiv) DOI: 10.1101/2023.04.19.537580

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

Sbierski-Kind*, Cautivo* et al. (Biorxiv) DOI: 10.1101/2023.04.26.537913

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Nakandakari-Higa et al. (BioRxiv) DOI: 10.1101/2023.03.16.533003

Glioblastoma induces the recruitment and differentiation of hybrid neutrophils from skull bone marrow

Lad BM et al. (BioRxiv) DOI:10.1101/2023.03.24.534105

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Rodríguez-Silvestre et al. (BioRxiv) DOI: 10.1101/2023.01.31.525875

Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer

Mahadevan K.K. et al. (BioRxiv) DOI: 10.1101/2023.03.05.531191

Unstable EBV latency drives inflammation in multiple sclerosis patient derived spontaneous B cells

Soldan S. et al. (Research Square) DOI: 10.21203/rs.3.rs-2398872/v1

Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

Palmeri J.R. et al. (BioRxiv) DOI:10.1101/2023.01.30.526116

A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8+ T Cells

Lerner*, Woroniecka* et al. (BioRxiv). DOI: 10.1101/2023.02.02.526713

A Distinct Phenotype of Polarized Memory B Cell holds IgE Memory

Koenig, J. et al. (BioRxiv) DOI: 10.1101/2023.01.25.525495

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

Li, J. et al. (BioRxiv) DOI: 10.1101/2023.01.13.523880

A conserved family of immune effectors cleaves cellular ATP upon viral infection

Rousset, F et al. (BioRxiv) DOI: 10.1101/2023.01.24.525353

Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumor effects

Towner et al. (BioRxiv) DOI: 10.1101/2023.01.04.522614

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacyoid dendritic cell haematopoiesis

Sikder M.A.A. et al. (BioRxiv) DOI: 10.1101/2023.01.05.522516

Human T follicular helper clones seed the germinal center-resident regulatory pool

Le Coz C. et al. (BioRxiv) DOI: 10.1101/2022.10.26.513910

Immunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics

Lozano-Rabella, M. et al. (BioRxiv) DOI: 10.1101/2022.11.07.514886

Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis

Cohen-Kedar, S. et al. (BioRxiv) DOI: 10.1101/2022.12.14.520372

B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis

Ulutekin, C. et al. (MedRxiv) DOI: 10.1101/2022.10.17.22281079

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s Disease

Daniels M.J.D. et al. (BioRxiv) DOI: 10.1101/2022.11.18.516922

Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state

Beltra J.-C. et al. (BioRxiv) DOI: 10.1101/2022.10.03.509766

Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

Ma Y. et al. (BioRxiv) DOI: 10.1101/2022.10.05.511036

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendrocytes

Garza R. et al. (BioRxiv) DOI: 10.1101/2022.09.07.506982

Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs

Bork F. et al. (BioRxiv) DOI: 10.1101/2022.07.26.499571

Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

Martinez-Riano A. et al. (BioRxiv) DOI: 10.1101/2022.09.06.506650

GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology

Earley Z. et al. (BioRxiv) DOI: 10.1101/2021.10.28.466194

Terminal differentiation and persistence of effector regulatory T cells essential for the prevention of intestinal inflammation

Dikiy S. et al. (BioRxiv) DOI: 10.1101/2022.05.16.492030

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

Buquicchio F. et al. (BioRxiv) DOI: 10.1101/2022.05.04.490680

Unaltered T cell responses to common antigens in individuals with Parkinson’s disease

Williams G.P. et al. (BioRxiv) DOI: 10.1101/2022.04.05.487195

Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

Weymar G.H.J. et al. (BioRxiv) DOI: 10.1101/2022.03.02.482683

In Utero Activation of NK Cells in Congenital CMV Infection

Vabeen A.V. et al. (BioRxiv) DOI: 10.1101/2022.04.04.487059

Induction of a CD8 T cell intrinsic DNA damage and repair response isassociated with clinical response to PD-1 blockade in uterine canc

Muroyama Y. et al. (BioRxiv) DOI: 10.1101/2022.04.16.488552

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

Cheng M. et al. (BioRxiv) DOI: 10.1101/2022.04.21.489076

Integrated protein and transcriptome high-throughput spatial profiling

Ben-Chetrit N. et al. (BioRxiv) DOI: 10.1101/2022.03.15.484516

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

Ayasoufi K. et al. (BioRxiv) DOI: 10.1101/2022.04.08.487707

STING controls T cell memory fitness during infection through Tcell intrinsic and IDO dependent mechanisms

Quaney M.J. et al. (BioRxiv) DOI: 10.1101/2022.03.19.484992

The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity.

Ho P. et al. (BioRxiv) DOI: 10.1101/2022.03.21.485049

Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates

Giles J.R. et al. (BioRxiv) DOI: 10.1101/2022.03.27.485974

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

De Silva N.S. et al. (BioRxiv) DOI: 10.1101/2022.02.17.480837

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Choi Y. et al. (BioRxiv) DOI: 10.1101/2022.01.26.477865

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

Chiaranunt P. et al. (BioRxiv) DOI: 10.1101/2022.03.23.485563

Germinal center block exacerbates extrafollicular responses and accelerates autoimmune disease progression in a murine lupus model

Voss L.F. et al. (BioRxiv) DOI: 10.1101/2022.03.04.482991

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

Mosallanejad K. et al. (BioRxiv) DOI: 10.1101/2022.03.09.483681

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

Baer J.M. et al. (BioRxiv) DOI: 10.1101/2022.02.09.479745

Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size

Zhou X., Franklin R. et al. (BioRxiv) DOI: 10.1101/2022.01.18.476683

Divergent clonal differentiation trajectories of T cell exhaustion

Daniel B. et al. (BioRxiv) DOI: 10.1101/2021.12.16.472900

The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanisms

Willett B.J. et al. (MedRxiv) DOI: 10.1101/2022.01.03.21268111

IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α

Van Dis E. et al. (BioRxiv) DOI: 10.1101/2021.12.16.473015

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

Masle-Farquhar E. et al. (BioRxiv) DOI: 10.1101/2021.12.20.473595